EUGENE, Ore. — Taylor Mikesell scored 28 points and No. 10 Oregon opened the season with a 116-51 win over Seattle on Saturday.
Sophomore center Sedona Prince had 17 points for Oregon, which shot 53.1% from the field while outrebounding the Redhawks 58-28. Senior forward Lydia Giomi added 15 points and 13 rebounds.
Mikesell, a junior transfer from Maryland, made seven 3-pointers in the first half, helping the Ducks to a 71-25 lead at the break.
Oregon (1-0) is replacing four starters after it went 32-2 last season, including three first-round picks in the WNBA draft.
Senior Erin Boley, the lone returning starter, had eight points and three rebounds.
Prince, a transfer from Texas, and Mikesell both got the start in their Oregon debuts, along with point guard Te-Hina Paopao, one of five freshmen who signed with the Ducks.
Junior Taylor Chavez, the Pac-12 sixth player of the year last season, resumed her role off the bench with 11 points.
Mikesell and Prince each scored nine points in the first quarter as Oregon shot 63.6% from the field to take a 39-14 lead.
Oregon pushed the lead to 94-41 at at the end of the third quarter.
Junior guard McKenzi Williams scored 20 points for Seattle (0-2), which shot 28.6% from the field.
Seattle: The Redhawks went 13-16 last year. Williams was the only player in double figures for the team.
Oregon: The Ducks dominated in what likely will be one of only two nonconference games before they open Pac-12 play at home next weekend against Colorado and Utah.
Seattle is scheduled to host Utah State on Thursday.
Oregon travels to face Portland on Monday night.